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Study-Design Notes & Translational Caution Because ATX-304 and SLU-PP-332 target different receptors and signaling layers, thoughtful study design is critical: Model choice: high-fat-diet mice, aged mice or cell lines with defined metabolic defects can clarify where each compound exerts the biggest effect

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In contrast to TAM injections, TAM chow increased neuronal differentiation of cells born during TAM but had no effect on density of EdU+ cells three weeks after TAM

It is dosed between 300 mcg and 1,000 mcg (1 mg) daily, either subcutaneously or via an intranasal applicator